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. 2015 May 7;6(17):15250–15264. doi: 10.18632/oncotarget.3888

Figure 2. Inhibition of the BRAF/MEK/ERK pathway induces RHOB in melanoma cells.

Figure 2

A and B. Western blotting of the indicated proteins in WM266-4 cells transfected with BRAF-targeting (si-BRAF1 and si-BRAF2) or non-targeting (si-Ctl) siRNAs (A) or treated for 48 h with 1 μM of BRAF (PLX4032 or SB590885) or MEK (AZD6244 or AS703026) inhibitors (B). C. Western blotting of RHOB, p-ERK and ERK in wild-type BRAF melanoma cell lines treated with 1 μM PLX4032 or AZD6244 for 48 h. D. Western blotting of RHOB, p-ERK and ERK in BRAFV600E colon cell lines treated with the indicated PLX4032 or AZD6244 concentrations for 48 h.