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. 2015 Apr 14;6(17):15297–15310. doi: 10.18632/oncotarget.3812

Figure 3. ATM inhibits PB1 domain-mediated interactions.

Figure 3

(A) Binding of GST-PKCζ (1-113, ▼) or GST (■) to Par6. Biotinylated Par6 was bound to streptavidin-coated plates and incubated with increasing concentrations of purified protein. Bound peptide was detected using the MesoScale Discovery detection system. (B) ATM inhibits binding of GST-PKCζ to Par6. Biotinylated Par6 bound to streptavidin-coated plates was incubated with 0.4μM of GST-PKCζ in the presence of increasing concentrations of ATM. The average of 3 replicates±SD is plotted and graph is representative of 2 or more independent experiments.