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(Combination index values (CI) values were calculated using CalcuSyn software CI>1 antagonism, CI=1, additive, CI<1, synergy [41])
| Drug | CI values at ED50 | CI values at ED75 | CI values at ED90 |
|---|---|---|---|
| R428 (alone) | N/A | N/A | N/A |
| Metformin (alone) | N/A | N/A | N/A |
| R428 and metformin (1:5000) | 1.16 | 1.00 | 0.87 |
