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. 2015 Apr 12;6(17):15375–15396. doi: 10.18632/oncotarget.3801

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Copyright: © 2015 Keerthikumar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(a) Biological pathways enriched in proteins that are more than 2-fold abundant in exosomes compared to ectosomes are displayed. Proteins implicated in ESCRT, syndecan signaling and membrane trafficking are enriched in exosomes. When proteins that are more than 2-fold abundant in ectosomes compared to exosomes were analysed using FunRich, proteins implicated in gene expression and translation were enriched in ectosomes. (b) Gene Ontology-based biological processes that are enriched and depleted in proteins differentially abundant in exosomes compared to ectosomes are displayed. (c) Gene Ontology-based molecular functions that are enriched and depleted in proteins differentially abundant in ectosomes compared to exosome are displayed.