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. 2015 Apr 24;6(17):15610–15627. doi: 10.18632/oncotarget.3639

Figure 5. Overexpressed PI3K with p85α plasmid reverses the effect of stably downregulated ENO1 and suppressed p-PI3K with Ly294002 (10 μM) reverses the effect of stably upregulated ENO1 in EC cells.

Figure 5

A–C. Overexpressed p85α in ENO1-suppressed EC cells restored cell proliferation, migration and invasion compared with ENO1 sliencing EC cells. D. Overexpressed p85α in ENO1-suppressed EC cells induced the protein levels of p-PI3K, p-AKT, c-Myc, Snail and LDHA. E–G. The promoting effect of stably overexpressed ENO1 in cell proliferation, migration and invasion was reversed by Ly294002 (10 μM) treatment. Data were presented as mean ± SEM for three independent experiments (*P < 0.05, **P < 0.01, ***P < 0.001).