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(A, B) LNCaP and DU145 were treated with 5 mM metformin, 5 mM AICAR (for malonyl-CoA), or 20 mM 2-DG (for NADPH) for 24 h. The concentrations of the malonyl-CoA and NADPH were determined as described in the Materials and Methods section. The graphs represent the results as the fold change versus CTL. **p < 0.01; ***p < 0.05.
