Table 4. Multivariate analysis of age, ER-, PR-status, lymph node, grade and 92-probe signature in relation to the patient's survival.
| Parameters | HR (95%CI) | p Value |
|---|---|---|
| Analysis without 92-probe signature | ||
| Age (years) | 0.996 (0.980–1.013) | 0.674 |
| ER status (+/–) | 0.570 (0.269–1.204) | 0.141 |
| PR status (+/–) | 1.148 (0.555–2.371) | 0.710 |
| Lymph node (+/–) | 1.799 (1.161–2.788) | 0.009 |
| Grade (1, 2, 3) | 1.536 (1.121–2.105) | 0.008 |
| Analysis with 92-probe signature | ||
| Age (years) | 0.996 (0.979–1.014) | 0.674 |
| ER status (+/–) | 1.111 (0.479–2.577) | 0.806 |
| PR status (+/–) | 1.269 (0.610–2.639) | 0.524 |
| Lymph node (+/–) | 1.856 (1.197–2.876) | 0.006 |
| Grade (1, 2, 3) | 1.382 (1.000–1.908) | 0.050 |
| 92-probe signature (low/high) | 2.746 (1.443–5.227) | 0.002 |
The multivariate model included 301 patients for DFS, owing to missing values in twenty two. A low risk was defined as a prognostic index less than or equal to −0.272144, and a high risk as a PI higher than −0.272144. HR, hazard ratio; CI, confident interval; ER, estrogen receptor; PR, progesterone receptor.