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. Author manuscript; available in PMC: 2016 Aug 28.
Published in final edited form as: Eur J Med Chem. 2015 Jul 8;101:525–533. doi: 10.1016/j.ejmech.2015.07.007

Scheme 2.

Scheme 2

Synthesis of compounds 25–30.

Reagents and conditions: i) SOCl2, Et3N, CHCl3, refluxing, 5 h. ii) 2-bromoethanol or 3-bromopropanol, DMAP, CHCl3, refluxing, 5 h. iii) amines, EtOH, refluxing, 18-24 h.