Table 1. Clinical and economic outcomes with navigation for one-time screening colonoscopy in a 10,000-person predominantly minority cohort, ages 50 to >80: Base case.

	No Screening	Colonoscopy without Navigation	Colonoscopy with Navigation
Screening Uptake	0%	40%	65%
CRC cases per 10,000 persons from entry until age 100	551	453	392
CRC stage
Localized	40%	41%	42%
Regional	37%	37%	37%
Distant	23%	22%	21%
CRC deaths per 10,000 persons	216	174	148
QALYs/person	15.4222	15.4439	15.4575
Cost/person	$2,814	$2,558	$2,422
ICER
No Screening	-	Dominates	Dominates
Colonoscopy without Navigation	-	-	Dominates
Colonoscopy with Navigation	-	-	-
Results by subpopulation
QALYs/person, African American*	14.2774	14.3012	14.3161
Cost/person, African American*	$3,276	$2,929	$2,734
QALYs/person, Hispanic*	16.4264	16.4458	16.4579
Cost/person, Hispanic*	$2,347	$2,184	$2,105
QALYs/person, White*	15.4349	15.4602	15.4761
Cost/person, White*	$3,258	$2,917	$2,727
QALYs/person, Age 55 at entry**	17.4717	17.4944	17.5086
Cost/person, Age 55 at entry**	$2,661	$2,480	$2,389
QALYs/person, Age 65 at entry**	13.7169	13.7398	13.7540
Cost/person, Age 65 at entry**	$3,058	$2,697	$2,495
QALYs/person, Age 75 at entry**	9.7467	9.7600	9.7684
Cost/person, Age 75 at entry**	$2,945	$2,597	$2,402
QALYs/person, Age 85 at entry**	5.9554	5.9610	5.9643
Cost/person, Age 85 at entry**	$2,271	$2,127	$2,061

^*57% age 50-59, 33% age 60-69, 9% age 70-79 and 1% age ≥80.

^**43% African American, 49% Hispanic, 4% White and 4% Other.

CRC, colorectal cancer; QALY, quality-adjusted life-year; ICER, incremental cost-effectiveness ratio.