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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Cell Rep. 2015 Aug 20;12(9):1430–1444. doi: 10.1016/j.celrep.2015.07.050

Figure 7. Lysosomal Ca2+, acidification, and enzyme activities are reduced in PS1KO neurons.

Figure 7

(A) Lysosomal Ca2+ (WT n=180; PS1KO n=181) was reduced and cytosolic Ca2+ (n=20) was elevated in PS1KO neurons In PS1KO neurons, (B) maturation of V0a1 and nicastrin was decreased and APP-CTF levels were increased; (C) AVs accumulate in both cell bodies and axons; (D) LysoTracker signal and in vivo CatB (E) and CatD (n=28) (F) activities were decreased Scale bars 10μm *** p<0.0001. Error bars: S.E.M