Skip to main content
. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Behav Brain Res. 2015 Jun 22;292:259–265. doi: 10.1016/j.bbr.2015.06.031

Figure 1.

Figure 1

Figure 1

Acute treatment with SSR149415 partly prevents the negative mood state associated with nicotine withdrawal. Effect of SSR149415 on brain reward thresholds (A) and response latencies (B) during nicotine withdrawal. Asterisks (*** P<0.001) indicate elevated brain reward thresholds compared to the corresponding control group. Plus signs (+ P<0.05, ++P<0.01) indicate lower brain reward thresholds compared to nicotine withdrawing rats that received vehicle (dose 0, icv). Saline n = 12, Nicotine n = 16. Data are expressed as means ± SEM.