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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Behav Brain Res. 2015 Jun 22;292:259–265. doi: 10.1016/j.bbr.2015.06.031

Figure 2.

Figure 2

Figure 2

Chronic treatment with SSR149415 completely prevents the negative mood state associated with nicotine withdrawal. Effect of chronic pretreatment with SSR149415 (0.5 µg) on brain reward thresholds (A) and response latencies (B) during nicotine withdrawal. Asterisks (*** P<0.001) indicate elevated brain reward thresholds compared to the corresponding control group. Plus sign (+ P<0.05) indicates lower brain reward thresholds compared to the nicotine withdrawing rats that received vehicle (icv). Saline-vehicle n = 9, saline-SSR149415 n=11, nicotine-vehicle n=8, nicotine-SSR149415 n=10. Data are expressed as means ± SEM.