Table 1.

The effect of clove oil and paracetamol on brewer's yeast-induced fever in mice

Group			Control	Paracetamola	Clove oila
	Dose (mg/kg)	–		100	33
	Initial body temperature	0 h	37.4±0.21	37.1±0.22	37.2±0.12
	Post-yeast temperature	17 h	39.2±0.25b*	39.5±0.12b**	39.0±0.17b**
		0.5 h	39.1±0.20b*	37.4±0.30c#	37.6±0.37c#
Rectal		% if		4.34	3.96
temperature (C°)		1 h	39.2±0.22b**	36.7±0.24c##	37.2±0.58c#
	Post-drug treatment	% if		6.40	5.18
		2 h	39.0±0.23b**	36.6±0.17c##	36.3±0.32c##
		% if		6.03	6.86
		3 h	38.9±0.19b*	36.3±0.27c##	37.0±0.29c##
		% if		6.88	5.09

Values are expressed as mean±SEM rectal temperature (n=6 each group). ANOVA followed by Tukey's multiple comparison tests.

^aAdministered 18 h after yeast injection

^bcompared to 0 h (paired t-test)

^ccompared to control group; % if=% inhibition of fever.

^*p<0.01

^**p<0.001

^#p<0.01

^##p<0.001 vs. control values.