Figure 5. Association between the number of coding genes and gene essentiality with the presence of homologs.
A) Total number of coding genes versus genes in multigene families: genes with same COG/NOG assignment in a genome were considered part of multigene families. B) Gene essentiality versus presence of a homolog in the genome: Fisher's exact tests were performed to assess the enrichment of essential genes in multigene families. Bars with one and two asterisks represent P ≤ 10−2 and P ≤ 10−5, respectively. For abbreviations of in vitro experiments refer to Figure 1. For in vivo experiments: ftula-invivo (F. tularensis novicida U112, in vivo); mtubeinvivo (Mycobacterium tuberculosis H37Rv, in vivo); and mtube-mac (Mycobacterium tuberculosis H37Rv, macrophages). For color codes, refer to Figure 3.