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. Author manuscript; available in PMC: 2016 Sep 4.
Published in final edited form as: Biochem Biophys Res Commun. 2015 Jul 17;464(4):1072–1077. doi: 10.1016/j.bbrc.2015.07.076

Figure 1.

Figure 1

Fibroblasts express the LXA4 receptor, ALX/FPR2. LXA4 regulates fibroblast migration and inhibits TGF-β1 induced fibroblast proliferation. Panel A: TGF-β1 upregulates ALX receptor expression analyzed by flow cytometry (PE-conjugated anti-ALX/FPR2 receptor antibody; p<0.05, n=4). Panel B: TGF-β1 increases fibroblast migration and scratch closure significantly at 24 hours (p<0.05). LXA4 slows fibroblast migration at 24 hours at both doses, returning to TGF-β1 alone values at 48 and 72 hours (p<0.05). Panel C: TGF-β1 stimulated an increase in fibroblast proliferation, analyzed by BrdU incorporation, and it is reduced by LXA4 (n=8; * = p<0.05 vs. control; # = p<0.05 vs. TGFβ1 alone).