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RvD2 regulates fibroblast function in vitro. All experiments were repeated with RvD2; a resolution agonist derived from the n-3 fatty acid DHA. Panel A: RvD2 inhibits scratch wound closure induced by TGF-β1 at 24 hours (p<0.05); closure rate is restored at 48 and 72 hours. Panel B: RvD2 inhibits TGF-β1 induced cell proliferation (p<0.05; n=5). Panels C and D: RvD2 has no significant effect on Collagen expression (A.U. = Arbitrary Units, n=4).
