Figure 1. αMyHC-Cre is cardiotoxic by six months of age.
(A) Ventricular contractile function (% Ejection fraction) at 3 months and 6 months. (B) Cardiac mass, heart weight normalized to body weight (HW/BW) at indicated ages. (C) Cardiac gene expression at 3 months in males and females (C) and 6 months, females (D), and males (E). Error bars: SEM, N=4–6/group *P < 0.05, **P < 0.01 vs. age-matched and sex-matched WT control.