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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Integr Biol (Camb). 2015 Jul 9;7(9):987–997. doi: 10.1039/c5ib00024f

Figure 3.

Figure 3

Parameterization and validation of ABM based on a diverse population of EB Movies. The vessel network characteristics of each EB Movie are not uniform and represent a diverse sampling of possible EC network architectures (A–C). Using three EB Movies the ABM Notch Transfer Coefficient was parameterized to predict the number of sprout initiations (D). The Notch Transfer Coefficient value of 0.6 was then tested in all other EB Movies. The number of sprout initiations observed in the EB Movies (red squares) is shown to fall within the 95% confidence interval of ABM predictions (black circles and error bars, E). Perfoming the same sweep of the Notch Transfer Coefficient from 0.0 through 2.0 for all EB Movies demonstrates a similar trend, possessing a linear response region from 0.0 to 1.0 (shaded region is one standard deviation, F,G).