Table 6.
Effect of B. longum on histomorphometric measurements of the femur.
| Parameters (%) | Sham | OVX | OVX + B. longum | p value |
|---|---|---|---|---|
| ObS/BS | 53.30 ± 2.29a | 37.05 ± 0.44c | 46.85 ± 1.42b | 0.046 |
| OcS/BS | 23.01 ± 1.34c | 27.96 ± 0.33a | 25.54 ± 1.23b | 0.001 |
| OS/BS | 24.02 ± 1.27a | 18.08 ± 0.17c | 23.06 ± 1.19b | 0.034 |
| OV/BV | 13.33 ± 1.28a | 7.06 ± 0.30c | 10.15 ± 1.19b | 0.004 |
| ES/BS | 28.97 ± 2.15c | 37.78 ± 0.30a | 34.24 ± 1.25b | 0.001 |
Ten-week-old female Sprague-Dawley rats were supplemented with 1 mL B. longum (108–109 CFU) once a day for 16 weeks, starting 2 weeks after surgery, while sham and OVX groups received 1 mL of demineralized water. At the end of the study, the percentage of osteoblast surface/bone surface (ObS/BS), osteoclast surface/bone surface (OcS/BS), eroded surface/bone surface (ES/BS), osteoid surface/bone surface (OS/BS), and osteoid volume/bone volume (OV/BV) was measured from H&E stained sections of the dissected femur. Values represent the mean ± SEM (n = 8 in each group).
abcValues with different letters in the same row are significantly different at p < 0.05 based on one-way ANOVA, followed by Tukey's post hoc test.