(a).
| Rank | Term | Count | Symbol | p value |
|---|---|---|---|---|
| KEGG | ||||
| 1 | hsa04110:Cell cycle | 14 | E2F1, CDK1, PRKDC, CDC20, MCM2, MCM3, YWHAE, MCM4, CDK2, MCM7, GSK3B, PCNA, BUB1B, MYC | 5.96E − 13 |
| 2 | hsa05215:Prostate cancer | 7 | E2F1, HSP90AB1, GRB2, GSK3B, MAPK3, PTEN, CDK2 | 2.62E − 05 |
| 3 | hsa04114:Oocyte meiosis | 7 | CDK1, PPP1CA, MAPK3, CDC20, AURKA, YWHAE, CDK2 | 8.70E − 05 |
| 4 | hsa03030:DNA replication | 5 | MCM7, PCNA, MCM2, MCM3, MCM4 | 9.48E − 05 |
| 5 | hsa05200:Pathways in cancer | 10 | E2F1, HSP90AB1, TRAF2, GRB2, MSH2, GSK3B, MAPK3, MYC, PTEN, CDK2 | 2.73E − 04 |
| 6 | hsa05213:Endometrial cancer | 5 | GRB2, GSK3B, MAPK3, MYC, PTEN | 4.03E − 04 |
| 7 | hsa05210:Colorectal cancer | 5 | GRB2, MSH2, GSK3B, MAPK3, MYC | 0.002457 |
| 8 | hsa05222:Small cell lung cancer | 5 | E2F1, TRAF2, MYC, PTEN, CDK2 | 0.002457 |
| 9 | hsa05214:Glioma | 4 | E2F1, GRB2, MAPK3, PTEN | 0.008946 |
| 10 | hsa04722:Neurotrophin signaling pathway | 5 | GRB2, GSK3B, MAPK3, YWHAE, TP73 | 0.009832 |
| 11 | hsa04115:p53 signaling pathway | 4 | CDK1, PTEN, CDK2, TP73 | 0.011029 |
| 12 | hsa05220:Chronic myeloid leukemia | 4 | E2F1, GRB2, MAPK3, MYC | 0.014381 |
| 13 | hsa04914:Progesterone-mediated oocyte maturation | 4 | HSP90AB1, CDK1, MAPK3, CDK2 | 0.020705 |
| 14 | hsa04012:ErbB signaling pathway | 4 | GRB2, GSK3B, MAPK3, MYC | 0.021345 |
| 15 | hsa04540:Gap junction | 4 | CDK1, GRB2, MAPK3, TUBA1B | 0.022657 |
| 16 | hsa05219:Bladder cancer | 3 | E2F1, MAPK3, MYC | 0.033366 |
| 17 | hsa04510:Focal adhesion | 5 | PPP1CA, GRB2, GSK3B, MAPK3, PTEN | 0.047655 |
| 18 | hsa05223:Non-small cell lung cancer | 3 | E2F1, GRB2, MAPK3 | 0.052694 |
| 19 | hsa05221:Acute myeloid leukemia | 3 | GRB2, MAPK3, MYC | 0.059845 |
| 20 | hsa04910:Insulin signaling pathway | 4 | PPP1CA, GRB2, GSK3B, MAPK3 | 0.064636 |
| 21 | hsa05218:Melanoma | 3 | E2F1, MAPK3, PTEN | 0.085159 |
| 22 | hsa04662:B cell receptor signaling pathway | 3 | GRB2, GSK3B, MAPK3 | 0.09351 |
|
| ||||
| BioCarte | ||||
| 1a | h_g1Pathway:Cell Cycle:G1/S Check Point | 4 | E2F1, CDK1, GSK3B, CDK2 | 0.012616 |
| 2a | h_p27Pathway:Regulation of p27 Phosphorylation during Cell Cycle Progression | 3 | E2F1, NEDD8, CDK2 | 0.020162 |
| 3a | h_p53Pathway:p53 Signaling Pathway | 3 | E2F1, PCNA, CDK2 | 0.033691 |
| 4a | h_her2Pathway:Role of ERBB2 in Signal Transduction and Oncology | 3 | GRB2, MAPK3, ESR1 | 0.049866 |
| 5a | h_ptenPathway:PTEN dependent cell cycle arrest and apoptosis | 3 | GRB2, MAPK3, PTEN | 0.054277 |
| 6a | h_RacCycDPathway:Influence of Ras and Rho proteins on G1 to S Transition | 3 | E2F1, MAPK3, CDK2 | 0.063496 |
| 7a | h_cellcyclePathway:Cyclins and Cell Cycle Regulation | 3 | E2F1, CDK1, CDK2 | 0.068295 |
The significant pathways via DAVID Bioinformatics database are selected for the 74 significant proteins in carcinogenesis. Bold indicates p value > 0.05. Most of them are from the KEGG database, and we add several key pathways from BioCarta.