(a).
| Rank | Term | Count | Symbol | p value |
|---|---|---|---|---|
| KEGG | ||||
| 1 | hsa04110:Cell cycle | 11 | E2F1, CCNB1, CDK1, CDKN2A, PCNA, BUB1B, PRKDC, CDC20, MCM2, MCM4, MYC | 4.90E − 11 |
| 2 | hsa03030:DNA replication | 4 | POLD1, PCNA, MCM2, MCM4 | 5.24E − 04 |
| 3 | hsa05220:Chronic myeloid leukemia | 4 | E2F1, CDKN2A, GRB2, MYC | 0.004415 |
| 4 | hsa04114:Oocyte meiosis | 4 | CCNB1, CDK1, CDC20, AURKA | 0.01273 |
| 5 | hsa05219:Bladder cancer | 3 | E2F1, CDKN2A, MYC | 0.015099 |
| 6 | hsa05223:Non-small cell lung cancer | 3 | E2F1, CDKN2A, GRB2 | 0.024285 |
| 7 | hsa05214:Glioma | 3 | E2F1, CDKN2A, GRB2 | 0.03234 |
| 8 | hsa04115:p53 signaling pathway | 3 | CCNB1, CDK1, CDKN2A | 0.037212 |
| 9 | hsa03430:Mismatch repair | 2 | POLD1, PCNA | 0.09922 |
|
| ||||
| BioCarta | ||||
| 1a | h_cellcyclePathway:Cyclins and Cell Cycle Regulation | 4 | E2F1, CCNB1, CDK1, CDKN2A | 0.002246 |
| 2a | h_srcRPTPPathway:Activation of Src by Protein-tyrosine phosphatase alpha | 3 | CCNB1, CDK1, GRB2 | 0.004 |
| 3a | h_g2Pathway:Cell Cycle:G2/M Checkpoint | 3 | CCNB1, CDK1, PRKDC | 0.025668 |
| 4a | h_g1Pathway:Cell Cycle:G1/S Check Point | 3 | E2F1, CDK1, CDKN2A | 0.039621 |
| 5a | h_ptc1Pathway:Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle | 2 | CCNB1, CDK1 | 0.075537 |
The significant pathways via DAVID Bioinformatics database are selected for the 43 significant proteins in carcinogenesis. Bold indicates p value > 0.05. Most of them are from the KEGG database, and we add several key pathways from BioCarta.