(a).
| Rank | Term | Count | Symbol | p value |
|---|---|---|---|---|
| KEGG | ||||
| 1 | hsa04110:Cell cycle | 16 | E2F1, CDK1, YWHAZ, YWHAB, CDC20, SFN, MCM2, MCM3, CDK4, MCM4, CDK2, MCM7, PCNA, YWHAQ, BUB1B, CCNA2 | 3.90E − 14 |
| 2 | hsa04114:Oocyte meiosis | 8 | CDK1, YWHAZ, YWHAB, YWHAQ, CDC20, AURKA, PPP1CC, CDK2 | 3.62E − 05 |
| 3 | hsa03030:DNA replication | 5 | MCM7, PCNA, MCM2, MCM3, MCM4 | 2.35E − 04 |
| 4 | hsa04115:p53 signaling pathway | 4 | CDK1, SFN, CDK4, CDK2 | 0.020496 |
| 5 | hsa03040:Spliceosome | 5 | SNRPB, THOC4, LSM2, SF3A2, SF3B4 | 0.022722 |
| 6 | hsa05222:Small cell lung cancer | 4 | E2F1, TRAF2, CDK4, CDK2 | 0.035432 |
| 7 | hsa04914:Progesterone-mediated oocyte maturation | 4 | HSP90AB1, CDK1, CCNA2, CDK2 | 0.037607 |
| 8 | hsa00310:Lysine degradation | 3 | SETDB1, WHSC1, EHMT2 | 0.055046 |
| 9 | hsa05200:Pathways in cancer | 7 | E2F1, HSP90AB1, TRAF2, MSH2, BIRC5, CDK4, CDK2 | 0.061178 |
|
| ||||
| BioCarte | ||||
| 1a | h_p53Pathway:p53 Signaling Pathway | 4 | E2F1, PCNA, CDK4, CDK2 | 0.003378 |
| 2a | h_cellcyclePathway:Cyclins and Cell Cycle Regulation | 4 | E2F1, CDK1, CDK4, CDK2 | 0.010334 |
| 3a | h_g1Pathway:Cell Cycle:G1/S Check Point | 4 | E2F1, CDK1, CDK4, CDK2 | 0.015615 |
| 4a | h_rbPathway:RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage | 3 | CDK1, CDK4, CDK2 | 0.019987 |
| 5a | h_ranMSpathway:Role of Ran in mitotic spindle regulation | 3 | RAN, AURKA, KPNA2 | 0.019987 |
| 6a | h_g2Pathway:Cell Cycle:G2/M Checkpoint | 3 | CDK1, YWHAQ, BRCA1 | 0.067509 |
| 7a | h_RacCycDPathway:Influence of Ras and Rho proteins on G1 to S Transition | 3 | E2F1, CDK4, CDK2 | 0.072809 |
The significant pathways via DAVID Bioinformatics database are selected for the 74 significant proteins in carcinogenesis. Bold indicates p value > 0.05. Most of them are from the KEGG database, and we add several key pathways from BioCarta.