Table 1.

% inhibition of sGC and SPR binding level of synthesised analogues of compound 10 to sGCcat

Compd number	R1	R2	R3	sGCcat (SPR) binding norm. resp. (RU)	sGC activity% inhibition at 100 μM
10	NO2	OH	H	14.4 ± 1.7	56.2 ± 22.4
14	NO2	H	OH	11.6 ± 0.8	41.4
15	NO2	OCH3	H	1.0 ± 0.3	—
16	NO2	H	H	2.6 ± 0.2	—
17	NO2	NHCOCH3	H	0.8 ± 0.3	—
18	NO2	H	NHCOCH3	3.0 ± 1.0	—
19	NO2	F	H	1.9 ± 1.8	—
20	H	OH	H	12.4 ± 0.1	—
21	CF3	OH	H	6.4 ± 0.5	44.4
22	CF3	H	OH	3.0 ± 0.5	21.1
23	CN	OH	H	4.5 ± 2	—
24	CN	H	OH	10.5 ± 0.5	—
25	Cl	OH	H	9.7 ± 0.5	—
26	Cl	H	OH	9.0 ± 0.4	—
27	CONHCH3	OH	H	1.1 ± 0.3	—
28	CONHCH3	H	OH	9.6 ± 0.3	—
29	NH2	OH	H	9.9 ± 0.2	—