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. 2015 Aug 28;47(8):e179. doi: 10.1038/emm.2015.54

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Copyright © 2015 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Proposed model for aggregation of wild-type α-SYN protein by TM-generated mutant α-SYN species and propagation. Mutant α-SYN generated through TM event may trigger a nucleation-dependent aggregation of the predominantly higher amount of wild-type species and lead to propagation of α-SYN aggregation.