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. 2015 Aug 6;6(8):e1845. doi: 10.1038/cddis.2015.200

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Inhibition of miR-587 sensitized colon cancer cells to 5-FU-induced apoptosis. (a) An miR-587 inhibitor decreased miR-587 expression in HCT116 and GEO cells as determined by quantitative real-time PCR. (b and c) The miR-587 inhibitor-treated or control cells were subjected to increasing concentrations of 5-FU for 72 h. MTT assays (b) and DNA fragmentation assays (c) showed increased sensitivity to 5-FU-induced apoptosis in the inhibitor-treated cells as compared with the control cells. The data are presented as the mean±S.D. of triplicate experiments. **P<0.01, ***P<0.001