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. 2015 Aug 6;6(8):e1843. doi: 10.1038/cddis.2015.216

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Homer1a protected neurons from NMDA injury in vitro. Cultured cortical neurons were infected by LVs carrying pGC-FU-EGFP-3FLAG vectors. A representative fluorescence image (Scale bar=100 μm, Left; 50 μm, Right; a). Homer1a expression was assessed by WB in cultured cortical neurons expressing different LVs. (b and c) After transfection and NMDA injury, caspase 3 cleavage was measured by WB (b and d), apoptotic rate was determined by Hoechst staining (e) and cytotoxicity was assessed by LDH assay (f). Data are represented as the mean±S.E.M. from five experiments. *P<0.05 versus the normal group; ^#P<0.05 versus the non-infection treatment (NT) and vector group; **P<0.05 versus the RNAi-Scr group