Figure 5.

The effect of Homer1a on the peak value of NMDAR currents in neurons and HEK293T cells. After LV-Flag-H1a infection of cultured cortical neurons, whole-cell patch clamp recordings were used to measure NMDAR currents, illustrated by a representative current image (a) and the bar graph of peak values (b). Expression of Homer1a, NR1 and NR2B in HEK293 cells transfected with NR1/NR2B receptors without (the control) or with Flag-H1a were detected by WB (c). Whole-cell patch clamp recordings were used to measure NMDAR currents in co-expressed HEK293 cells, illustrated by a representative current image (d) and the bar graph of peak values (e). Data were represented as mean±S.E.M. obtained from five experiments.*P<0.05 versus the NT group