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. 2015 Aug 27;6(8):e1860. doi: 10.1038/cddis.2015.219

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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α-Solanine activated UPR pathway. (a) A549 cells were exposed to 10 μM α-solanine and harvested at indicated time points. Cell lysates were subjected to western blot assay to determine activation of UPR pathway and band intensities were quantified. (b) ER calcium ion release in α-solanine (10 μM, 24 h) treated cells was investigated by fluorescence microscopy after staining with 5 μM Fluo-4AM. (c) A549 cells were transfected with non-targeting or PERK siRNA and treated with α-solanine for 24 h. The corresponding proteins were evaluated by immunoblotting and band intensities were quantified