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. 2015 Aug 13;6(8):e1854. doi: 10.1038/cddis.2015.226

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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GADD45β-I peptide protects against thromboembolic ischemia. Rats were pre-treated with vehicle (a) or GADD45β-I (11 mg/kg, 30 min before lesion) (b) and killed 24 h post lesion. Brains from control (a) and GADD45β−I-treated (b) rats were extracted and colored with TTC staining to show ischemic region. Images 6A–B are TTC-stained representative slices of the two experimental groups (scale bar=1 mm). In addition, we show a full reconstruction of the lesion size (blue shade on gray) obtained with contour analysis through Neurolucida software. (c) Percentage of ischemic volume was measured with Neurolucida software and Cavalieri's geometry Treated animals were compared with untreated animals. Data represent mean±S.D. (Student's t-test **P<0.05, n=3)