Table 2. Site of Type I functional divergence.

Groups	0.9 > Qk > 0.67	Qk > 0.9
Cry1a/Cry1b -fish	92K,94N,114K,125I,137K,162A,165T,179T,219T,305R,311G,479L
Cry1a/Cry1- tetrapod	125I, 179T, 183S, 203E, 248Y, 392M, 437R, 441H, 454V
Cry1a/Cry2- tetrapod	118N, 126V, 128I, 137K, 162A, 168E, 180T, 181P, 189K, 211P, 311G, 461I
Cry1a/Cry2- fish	93I,94N,114K,118N,128I,137K,161E,162A,172A,174V,181P,183S,189K,201D,203E,211P,222E,233N,236R,237P,239M,241A,265F,281S,305R,459K,472H,479L,
Cry1a/Cry3 Fish + tetropod	53R,57Q,58C,63D,65S,67R,79Q,82D,83V,89K,92N,93I,100Y,111A,112A,115K,116L,120A,121G,128I,137K,139I,140E,146S,157I,159R,161E,173E,174V,180T,183S,189K,190F,193P,194S,196E,208A,209V,211P,216E,223R,225L,226E,227R,234F,235E,247S,264L,271D,274R,281S,283P,299A,314I,318I,319P,324P,338P,372I,373S,378M,386L,408Q,417S,427D,428Y,443Y,454V,456K,459K,461I,470M,482E,485K,	94, 305, 311

148 sites were investigated based on posterior probability (Qk) within CRY proteins. Sites with 0.9 > Qk > 0.67 or Qk > 0.9 are listed relative to zebrafish Cry1aa protein sequence. Sites located at N-terminal regions RD-2a, RD-1 or RD-2b are high-lighted in yellow, green or blue, respectively.