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. 2015 Aug 24;5(8):e179. doi: 10.1038/nutd.2015.29

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Creb3l4 KO mice show impaired glucose tolerance and decreased insulin sensitivity. (a, b) Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) responses (0–120 min) performed after 14 and 15 weeks of LFD feeding, respectively (c, d) Fasting glucose, plasma insulin, adiponectin and resistin levels from WT or Creb3l4 KO mice fed an LFD for 16 weeks. (e) Relative expression of adipogenic genes, macrophage marker genes and lipogenenic genes in epididymal white adipose tissue, normalized to the housekeeping gene Rplp0. Values are expressed as means±s.e.ms., n=6–7 in panels (a) and (c), n=4–5 in panels (b, d and e), *P<0.05 for Creb3l4 KO versus WT mice.