Table 2. Extended Cox regression analysis of factors predicting risk of developing oligoanuria.
|
Full model |
Reduced model |
|||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
| Male sex | 0.961 | (0.616–1.498) | 0.861 | |||
| Age at initiation of PD (year) | 0.953 | (0.899–1.011) | 0.112 | 0.953 | (0.914–0.992) | 0.026 |
| Puberty | 0.918 | (0.503–1.654) | 0.777 | |||
| BMI s.d. scores | 1.148 | (0.952–1.391) | 0.153 | 1.154 | (0.965–1.386) | 0.121 |
| Estimated fluid excess (%) | 1.102 | (1.006–1.200) | 0.030 | 1.080 | (0.993–1.163) | 0.056 |
| Systolic blood pressure s.d. scores | 0.963 | (0.834–1.109) | 0.606 | |||
| Underlying diagnosis (reference: CAKUT) | ||||||
| Glomerulopathies | 4.134 | (2.339–7.527) | <.0001 | 4.776 | (2.791–8.467) | <0.0001 |
| Other | 2.160 | (1.012–4.541) | 0.043 | 2.607 | (1.272–5.238) | 0.015 |
| Initial urine output (l/m2 per day) | 0.470 | (0.285–0.743) | 0.002 | 0.441 | (0.278–0.672) | <0.0001 |
| Medications | ||||||
| RAS antagonists | 1.603 | (0.979–2.631) | 0.061 | 1.546 | (1.018–2.346) | 0.040 |
| Diuretics | 0.170 | (0.041–0.475) | 0.003 | 0.178 | (0.043–0.486) | 0.004 |
| PD modality (reference: CAPD) | ||||||
| NIPD | 0.974 | (0.422–2.406) | 0.952 | |||
| CCPD | 0.861 | (0.407–1.990) | 0.714 | |||
| PD fluids | ||||||
| Biocompatible PD fluid | 0.881 | (0.453–1.716) | 0.710 | |||
| Icodextrin | 2.380 | (1.327–4.196) | 0.003 | 2.285 | (1.364–3.699) | 0.001 |
| Ultrafiltration volume (l/m2 per day) | 1.811 | (1.328–2.462) | <.0001 | 1.885 | (1.253–2.120) | <0.0001 |
| No. of peritonitis episodes | 0.992 | (0.790–1.205) | 0.937 | |||
| Nephrotoxic drug exposure (days) | 0.905 | (0.751–1.067) | 0.263 | |||
| Region of residence (reference: Europe) | ||||||
| United States | 0.928 | (0.279–2.623) | 0.895 | |||
| Latin America | 0.563 | (0.230–1.349) | 0.201 | |||
| Turkey | 0.905 | (0.751–1.067) | 0.263 | |||
| Asia | 1.050 | (0.473–2.280) | 0.090 | |||
Abbreviations: BMI, body mass index; CAKUT, congenital anomalies of kidney and urinary tract; CAPD, continuous ambulatory peritoneal dialysis; CCPD, continuous cycling peritoneal dialysis; CI, confidence interval; GFR, glomerular filtration rate; HR, hazard ratio; PD, peritoneal dialysis; NIPD, nocturnal intermittent peritoneal dialysis; RAS, renin–angiotensin system.