Table 2. Characteristics of patients included in the study at baseline and according to the presence or absence of, at least, a mutation.
| Variable | Total (n=180) | (A) Mutated cases (n=40) | (B) Non-mutated cases (n=140) | P (A vs B) |
|---|---|---|---|---|
| Age, years, (mean±s.d.) | 69±1 | 70±12 | 68±11 | 0.9 |
| Sex, male/female,% (n) | 59 (107)/41 (74) | 67 (27)/33 (13) | 60 (85)/40 (55) | 0.3 |
| Rai Stage, % | ||||
| 0 | 45 | 38 | 49 | 0.3 |
| I | 48 | 52 | 47 | 0.5 |
| II | 7 | 10 | 4 | 0.3 |
| Leukocytes, x109/l (median, IQR) | 15.3 (10.9–26.9) | 16.6 (10.9–24.2) | 14.6 (10.7–24) | 0.2 |
| Lymphocytes, x109/l (median, IQR) | 10.3 (7–19.8) | 12.2 (7.3–20.6) | 9.8 (7–16) | 0.3 |
| B-cell count, x109/l (median, IQR) | 9.1 (6.1–17.3) | 11.2 (7.4–19.1) | 8.9 (6–15.6) | 0.3 |
| Hemoglobin, g/dl (median, IQR) | 13.8 (12.2–14.7) | 13.7 (12–14.5) | 13.8 (12.3–14.7) | 0.6 |
| Platelets, x109/l (median, IQR) | 182 (136–217) | 168 (126–216) | 187 (136–217) | 0.6 |
| LDH IU/l (median, IQR) | 368 (323–425) | 377 (318–453) | 324 (288–390) | 0.4 |
| B2microglobulin, mg/l (median, IQR) | 2.2 (1.8–3) | 2.4 (1.8–3.6) | 2.2 (1.7–3) | 0.3 |
| ZAP70 +, % (n) | 42 (76) | 50 (20) | 40 (56) | 0.1 |
| CD38 +, % (n) | 28 (50) | 38 (15) | 22 (30) | 0.1 |
| IgHV-unmutated status, % (n) | 34 (61) | 43 (17) | 27 (37) | 0.07 |
| FISH abnormalities, % (n) | ||||
| Del(13q) | 46 (84) | 50 (20) | 47 (65) | 0.7 |
| +12 | 18 (32) | 25 (10) | 14 (20) | 0.2 |
| Del(11q) | 5 (8) | 17 (7) | 1 (0.7) | 0.01 |
| Del(17p) | 2 (4) | 10 (4) | 2 (1.4) | 0.02 |
Abbreviations: CD38, cluster of differentiation 38; FISH, fluorescence in situ hibridization; IgVH, immunoglobulin heavy-chain variable region gen; IQR, interquartile range; LDH, lactate dehydrogenase; ZAP70, Zeta-chain-associated protein kinase 70; +12, trisomy 12. Bold face: del(11q) and del (17p) as variables distributed differently among mutated or not mutated patients with statistical significance (P=0.014)
.
Note: quantitative variables with a normal distribution are expressed as mean±s.d. Quantitative variables not following the normal distribution are expressed as median and interquartile ranges.