Table 3A. Multivariate Cox regression for time to first treatment.
| Variable | RR (95% CI) | P-value |
|---|---|---|
| TP53 | 3.9 (1.4–10.9) | 0.01 |
| IgVH | 2 (0.9–4.4) | 0.08 |
| NOTCH1 | 1.9 (0.7–5.7) | 0.2 |
| ATM | 1.9 (0.7–4.6) | 0.17 |
| +12 | 1.3 (0.6–2.7) | 0.4 |
| CD38 | 2.3 (1–5.3) | 0.04 |
| SF3B1 | 2.6 (0.8–8) | 0.09 |
| Rai Stage>0 | 1.1 (0.5–2.3) | 0.7 |
| B-cell count ⩾10 × 109/l | 1.9 (0.9–3.9) | 0.08 |
| β2-microglobulin ⩾2.4 | 2.4 (1.2–4.8) | 0.02 |
Abbreviations: CD38, cluster of differentiation 38; CI, confidence interval; IgVH, immunoglobulin heavy-chain variable region gen; RR, relative risk; +12, trisomy 12. Bold face: variables reaching the independent statistical significance.