Table 1. Clinical and laboratory features of 41 patients with AML, stratified by Twist1 expression level.
| Twist1(+) (n=22) | Twist1(−) (n=19) | P-value | |
|---|---|---|---|
| Age (years) | 58.1±16.9 | 62.5±17.6 | 0.410 |
| Male, n (%) | 13 (59.1%) | 11 (57.9%) | 1.000 |
| WBC (× 109/l) | 55.7±75.5 | 38.4±74.1 | 0.466 |
| Hemoglobin (g/dl) | 7.9±2.3 | 8.7±2.5 | 0.325 |
| Platelet count (× 109/l) | 47±36 | 129±206 | 0.103 |
| Platelet count <150 × 109/l, n (%) | 22 (100%) | 14 (73.7%) | 0.016 |
| ANC<0.5 × 109/l, n (%) | 6 (27.3%) | 1 (5.3%) | 0.099 |
| PB myeloblast ⩾30%, n (%) | 17 (77.3%) | 7 (36.8%) | 0.012 |
| LDH (U/dl) | 1071±1976 | 461±666 | 0.223 |
| LDH<1.5 × UNL, n (%) | 4 (28.6%) | 10 (55.6%) | 0.086 |
| Uric acid (g/dl) | 6.9±4.4 | 7.0±2.9 | 0.938 |
| Albumin (g/dl) | 2.8±0.7 | 3.4±0.6 | 0.024 |
| BM cellularity (%) | 86.0±15.4 | 88.9±14.5 | 0.541 |
| BM blast (%) | 76.0±23.7 | 72.9±20.6 | 0.665 |
| BM fibrosis, nil or mild, n (%) | 19 (90.5%) | 13 (81.3%) | 0.634 |
| Extramedullary involvement (+), n (%) | 4 (18.2%) | 3 (15.8%) | 1.000 |
Abbreviations: AML, acute myeloid leukemia; ANC, absolute neutrophil count; BM, bone marrow; LDH, lactate dehydrogenase; PB, peripheral blood; UNL, upper normal limit; WBC, white blood cell count. Values are reported as mean±s.d. unless otherwise indicated. P-values with statistically significant differences are shown in bold.