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. 2015 Sep 3;5:13497. doi: 10.1038/srep13497

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Copyright © 2015, Macmillan Publishers Limited

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Tissue was collected for immunohistochemical and mRNA analyses at varying time points after induction of CCI (A). Under physiological conditions pericytes were located in a typical perivascular manner within the cerebral cortex (Claudin 5: green; PDGFRß: red). Only few cells were positive for Ki67, a marker for cell proliferation (B). Three days after CCI PDGFRß positive cells at the CCI border were associated with a strong increase of Ki67 immunoreactivity (C). Five days after CCI a prominent increase of PDGFRß expressing cells was detected (D). Panel E shows an orthogonal section view of a pericontusional pericyte positive for Ki67 that is not in contact with a microvessel. Quantification of PDGFRß staining demonstrates an initial loss of PDGFRß that is followed by a significant increase of PDGFRß 5 days after CCI (F). N = 5–6 animals per group; *P < 0.05; **P < 0.01.