Table 1. Pharmacokinetic parameters of metformin following a single administration of voglibose/metformin 0.2/500 mg fixed-dose combination (FDC) vs. co-administered voglibose 0.2 mg and metformin 500 mg in 28 healthy subjects.
| Parameter | Voglibose/metformin FDC | Coadministered voglibose and metformin |
|---|---|---|
| Cmax, (µg/mL) | 1.38 (1.35) ± 0.32 | 1.35 (1.32) ± 0.30 |
| AUC0–t, (µg×h/mL) | 8.17 (8.01) ± 1.65 | 7.63 (7.48) ± 1.54 |
| AUC0–∞, (µg×h/mL) | 8.28 (8.13) ± 1.65 | 7.73 (7.58) ± 1.54 |
| tmax, (h) | 2.5 (1 ~ 4) | 2.5 (0.5 ~ 4) |
| t1/2, (h) | 4.08 ± 0.62 | 4.20 ± 0.69 |
All values are arithmetic mean (geometric mean) ± standard deviation except tmax is median (range).