Table 1.
The top five terms of Gene Ontology category analysis for the up-regulated differentially expressed genes
| Category | Term | Name | Counts | Gene symbol | p value |
|---|---|---|---|---|---|
| Biological process | GO:0034976 | Response to endoplasmic reticulum stress | 21 | AARS, CCND1, FAM129A, GSK3B, … | 3.17E−10 |
| GO:0006418 | tRNA aminoacylation for protein translation | 12 | AARS, PARS2, TARS, YARS, … | 3.41E−08 | |
| GO:0043038 | Amino acid activation | 12 | AARS, PARS2, TARS, YARS, … | 7.23E−08 | |
| GO:0043039 | tRNA aminoacylation | 12 | AARS, PARS2, TARS, YARS, … | 7.23E−08 | |
| GO:0034620 | Cellular response to unfolded protein | 14 | AARS, CCND1, SERP1, STC2, … | 1.35E−06 | |
| Molecular function | GO:0004812 | Aminoacyl-tRNA ligase activity | 12 | AARS, PARS2, TARS, YARS, … | 6.72E−09 |
| GO:0016875 | Ligase activity, forming carbon-oxygen bonds | 12 | AARS, PARS2, TARS, YARS, … | 6.72E−09 | |
| GO:0016876 | Ligase activity, forming aminoacyl-tRNA and related compounds | 12 | AARS, PARS2, TARS, YARS, … | 6.72E−09 | |
| GO:0015175 | Neutral amino acid transmembrane transporter activity | 7 | SLC1A4, SLC1A5, SLC3A2, SLC7A5, … | 2.70E−06 | |
| GO:0015171 | Amino acid transmembrane transporter activity | 9 | SLC1A4, SLC1A5, SLC3A2, SLC7A5, … | 1.74E−4 | |
| Cellular components | GO:0043231 | Intracellular membrane-bounded organelle | 370 | CCND1, COL1A2, EEF1A2, GADD45A, … | 5.07E−06 |
| GO:0043227 | Membrane-bounded organelle | 371 | CCND1, COL1A2, EEF1A2, GADD45A, … | 5.19E−06 | |
| GO:0005622 | Intracellular | 448 | AARS, CCND1, EEF1A2, GADD45A, … | 3.09E−05 | |
| GO:0044424 | Intracellular part | 443 | AARS, CCND1, EEF1A2, GADD45A, … | 4.49E−05 | |
| GO:0005737 | Cytoplasm | 346 | AARS, CD9, CCND1, EEF1A2, … | 8.23E−05 |