Table 2.
Pathway enrichment of the up-regulated differentially expressed genes
| Pathway | Term | Name | Count | Gene symbol | p value |
|---|---|---|---|---|---|
| KEGG pathway | 970 | Aminoacyl-tRNA biosynthesis | 12 | AARS, PARS2, TARS, YARS, … | 6.95E−07 |
| 260 | Glycine, serine, and threonine metabolism | 5 | CBS, CTH, PHGDH, PSAT1, SHMT2 | 3.5E−03 | |
| 532 | Glycosaminoglycan biosynthesis-chondroitin sulfate | 4 | CHPF, CHST15, UST, XYLT1 | 5.2E−03 | |
| 565 | Ether lipid metabolism | 5 | ENPP2, LPCAT1, PLA2G12A, PLA2G4A, PPAP2B | 6.0E−03 | |
| REACTOME pathway (top ten terms) | 379716 | Cytosolic tRNA aminoacylation | 10 | AARS, PARS2, TARS, YARS, … | 1.50E−09 |
| 379724 | tRNA aminoacylation | 12 | AARS, PARS2, TARS, YARS, … | 5.17E−09 | |
| 352230 | Amino acid transport across the plasma membrane | 8 | SLC1A4, SLC1A5, SLC3A2, SLC7A5, … | 4.75E−06 | |
| 425374 | Amino acid and oligopeptide SLC transporters | 9 | SLC1A4, SLC1A5, SLC3A2, SLC7A5, … | 2.39E−05 | |
| 380994 | Activation of genes by ATF4 | 4 | ASNS, ATF3, DDIT3, HERPUD1 | 3.61E−05 | |
| 70614 | Amino acid synthesis and interconversion (transamination) | 5 | ASNS, GLS, GPT2, PHGDH, PSAT1 | 0.000160459 | |
| 381042 | PERK regulated gene expression | 4 | ASNS, ATF3, DDIT3, HERPUD1 | 4.48E−04 | |
| 1614603 | Cysteine formation from homocysteine | 2 | CBS, CTH | 1.1E−03 | |
| 73943 | Reversal of alkylation damage by DNA dioxygenases | 2 | ALKBH2, ALKBH3 | 1.1E−03 | |
| 73942 | DNA damage reversal | 2 | ALKBH2, ALKBH3 | 3.1E−03 |
KEGG Kyoto Encyclopedia of Genes and Genomes