Table 3.

The top five terms of Gene Ontology category analysis for the down-regulated differentially expressed genes

Category	Term	Name	Counts	Gene symbol	p value
Biological process	GO:0000226	Microtubule cytoskeleton organization	46	AURKA, AURKB, CCNB1 CDK1, CENPA, FBXO5, …	0
	GO:0000278	Mitotic cell cycle	119	AURKA, AURKB, CCNE2, CDK1, CENPA, CENPH, FBXO5, RRM2, …	0
	GO:0000280	Nuclear division	68	AURKA, AURKB, CCNB1, CCNB2, CENPE, …	0
	GO:0006996	Organelle organization	164	AURKA, AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPE, CENPH, …	0
	GO:0007017	Microtubule-based process	59	AURKA, AURKB, CCNB1, CDK1, CENPA, FBXO5, …	0
Molecular function	GO:0005515	Protein binding	334	AURKA, AURKB, CCNB1, CCNB2, CCNE2, CDK1, HMGB2, …	8.15E−13
	GO:0000166	Nucleotide binding	122	AURKA, AURKB, CDK1, CENPE, EEF1A1, …	1.32E−07
	GO:1901265	Nucleoside phosphate binding	122	AURKA, AURKB, CDK1, CENPE, EEF1A1, …	1.35E−07
	GO:0036094	Small molecule binding	127	AURKA, AURKB, CDK1, CENPE, EEF1A1, …	2.24E−07
	GO:0008017	Microtubule binding	19	CENPE, KIF14, KIF15, PLK1, …	8.25E−07
Cellular components	GO:0000775	Chromosome, centromeric region	37	AURKB, BUB1, CCNB1, CENPA, CENPH, …	0
	GO:0000776	Kinetochore	29	CCNB1, CENPA, CENPE CENPH, KIF22, …	0
	GO:0000777	Condensed chromosome kinetochore	27	CCNB1, CENPA, CENPE CENPH, KIF2C, …	0
	GO:0000779	Condensed chromosome, centromeric region	28	AURKB, CCNB1, CENPA, CENPE, CENPH, …	0
	GO:0000793	Condensed chromosome	42	AURKB, CCNB1, CENPA, CENPH, KIF2C, …	0