Table 15:
Pregnancy Reports in Cohort Studies After MRgHIFU Treatment of Uterine Fibroids
| Country, Author, Year, | Cohort Size, Age, Mean ± SD (range) | Follow-Up Duration | Pregnancies | Pregnancy Outcomes |
|---|---|---|---|---|
| Germany, Froeling V et al, 2013 (126) | 50 women 36.1 years (27–41 years) | 24 months | 9 women had 10 pregnancies | Pregnancies occurred on average 16.1 months (range, 8.5–23.8) after MRgHIFU. There were 7 live births and 3 miscarriages. |
| Japan, Funaki K et al, 2009 (73) | 91 women 40.4 ± 4.6 years | 24 months | 4 pregnancies | 1 pregnancy occurred 3 months after MRgHIFU, 2 at 12 months, and 1 within 24 months. There were 2 live full-term births and 2 first-trimester miscarriages. |
| Japan, Morita Y et al, 2008 (96) | 48 women 42.2 ± 5.8 years (24–51 years) | 12 months | 1 pregnancy | 1 pregnancy occurred 4 months after MRgHIFU in a 29-year-old women with no previous pregnancy. There was a 39-week vaginal delivery of a normal 3,212-g baby with Apgar scores of 8 and 9 and an uneventful postpartum course. |
| Chinaa, Qin J et al, 2012 (54) | 435 women 34.5 ± 4.5 years (25–42 years) | 12 months | 24 women had 24 pregnancies | Of the 24 women, 8 had desired pregnancy while remaining 16 had not. Only 1 woman had been diagnosed with secondary infertility. Conception occurred following USgHIFU at < 3 months (n = 4), 3–6 months (n = 13), and > 7 months (n = 7). Of the 8 desiring pregnancy, 7 continued to elective Caesarean section at full term with birth weights at least 2,500-g and Apgar scores within normal ranges (8–9) in all cases. |
| Korea, Yoon S-W et al, 2013 (111) | 60 women 41.3 ± 6.3 years (30–52 years) | 12 months | 1 pregnancy | 1 pregnancy occurred 4 months following MRgHIFU and resulted in a successful delivery. |
Abbreviations: MRgHIFU, magnetic resonance–guided high-intensity focused ultrasound; SD, standard deviation; USgHIFU, ultrasound-guided high-intensity focused ultrasound.
a
Women in this study underwent ultrasound-guided HIFU.