Table 10:
One-Way Sensitivity Analyses—Cost-Effective Strategies Based on Willingness-to-Pay Thresholds
| Parameters | Values | Cost-Effective Strategy Based on WTP | |
|---|---|---|---|
| $50,000/QALY | $100,000/QALY | ||
| Utility of symptomatic fibroid (base-case) | 0.6700 | UAE | UAE |
| Low | 0.5000 | Hysterectomy | Hysterectomy |
| High | 0.7800 | MRgHIFU | UAE |
| Utility of symptomatic relief (base-case) | 0.7600 | UAE | UAE |
| Low | 0.6000 | MRgHIFU | UAE |
| High | 0.9000 | Hysterectomy | Hysterectomy |
| Disutility for post hysterectomy (base-case) | 0.0150 | UAE | UAE |
| Low | 0.0120 | Hysterectomy | UAE |
| High | 0.0180 | UAE | UAE |
| Cost of hysterectomy procedure (base-case) | $6,479.72 | UAE | UAE |
| Low | $5,183.78 | Hysterectomy | UAE |
| High | $7,775.66 | UAE | UAE |
| Cost of UAE procedure (base-case) | $4,269.55 | UAE | UAE |
| Low | $3,415.64 | UAE | UAE |
| High | $5,123.46 | Hysterectomy | UAE |
| Cost of MRgHIFU procedure (base-case) | $3,498.59 | UAE | UAE |
| Low | $2,798.87 | MRgHIFU | UAE |
| High | $4,198.31 | UAE | UAE |
| Probability of recurrence, UAE (base-case) | 0.0300 | UAE | UAE |
| Low | 0.0240 | UAE | UAE |
| High | 0.0360 | Hysterectomy | MRgHIFU |
| Cost of monitoring for UAE & MRgHIFU (base-case) | $152.58 | UAE | UAE |
| Low | $122.06 | UAE | UAE |
| High | $183.09 | Hysterectomy | UAE |
| Probability for recurrence, MRgHIFU (base-case) | 0.0600 | UAE | UAE |
| Low | 0.0480 | MRgHIFU | MRgHIFU |
| High | 0.0720 | UAE | UAE |
| Cost of screening for UAE & MRgHIFU (base-case) | $862.91 | UAE | UAE |
| Low | $690.33 | UAE | UAE |
| High | $1,035.49 | UAE | UAE |
| Disutility during hysterectomy recovery (base-case) | 0.2000 | UAE | UAE |
| Low | 0.1600 | UAE | UAE |
| High | 0.2400 | UAE | UAE |
| Probability for recurrence, myomectomy (base-case) | 0.0500 | UAE | UAE |
| Low | 0.0400 | MRgHIFU | UAE |
| High | 0.0600 | UAE | UAE |
| Cost of monitoring for hysterectomy & myomectomy (base-case) | $91.83 | UAE | UAE |
| Low | $73.46 | Hysterectomy | UAE |
| High | $110.19 | UAE | UAE |
| Cost of myomectomy procedure (base-case) | $6,050.71 | UAE | UAE |
| Low | $4,840.57 | UAE | UAE |
| High | $7,260.85 | Hysterectomy | UAE |
| Probability for procedure related death, hysterectomy (base-case) | 0.0020 | UAE | UAE |
| Low | 0.0016 | UAE | UAE |
| High | 0.0024 | UAE | UAE |
| Probability for procedure related death, UAE (base-case) | 0.0015 | UAE | UAE |
| Low | 0.0012 | UAE | UAE |
| High | 0.0018 | UAE | UAE |
| Discount Rate (base-case) | 0.050 | UAE | UAE |
| Low | 0 | UAE | UAE |
| High | 0.0300 | UAE | UAE |
| Cost of screening for hysterectomy & myomectomy (base-case) | $472.16 | UAE | UAE |
| Low | $377.73 | UAE | UAE |
| High | $566.59 | UAE | UAE |
| Probability for complications, UAE (base-case) | 0.0340 | UAE | UAE |
| Low | 0.0272 | UAE | UAE |
| High | 0.0408 | UAE | UAE |
| Probability for complications, myomectomy (base-case) | 0.0210 | UAE | UAE |
| Low | 0.0168 | UAE | UAE |
| High | 0.0252 | UAE | UAE |
| Probability for complications, hysterectomy (base-case) | 0.0200 | UAE | UAE |
| Low | 0.0160 | UAE | UAE |
| High | 0.0240 | UAE | UAE |
| Probability for complications MRgHIFU (base-case) | 0.0130 | UAE | UAE |
| Low | 0.0104 | UAE | UAE |
| High | 0.0156 | UAE | UAE |
| Portion eligible for MRgHIFU | 0.3500 | UAE | UAE |
| Low | 0.2500 | UAE | UAE |
| High | 0.4500 | MRgHIFU | UAE |
| Proportion Eligible for UAE | 0.9000 | UAE | UAE |
| Low | 0.8000 | Hysterectomy | UAE |
Abbreviations: MRgHIFU, magnetic resonance-guided high-intensity focused ultrasound; QALY, quality-adjusted life-year; UAE, uterine artery embolization; WTP, willingness to pay.