Table 1:

Body of Evidence Examined According to Study Design

	Study Design	Number of Eligible Studies
RCT Studies
Systematic review of RCTs
Large RCT
Small RCT		1
Observational Studies
Systematic review of non-RCTs with contemporaneous controls
Non-RCT with non-contemporaneous controls		2 (3 citations)
Systematic review of non-RCTs with historical controls
Non-RCT with historical controls		1
Database, registry, or cross-sectional study		2
Case series		7 (8 citations)
Retrospective review, modelling
Studies presented at an international conference
Expert opinion
Total		13 (15 citations)

Abbreviation: RCT, randomized controlled trial.