Table 4.

Thromboembolic potential of CDP7657 in an extended 3-month study in Rhesus monkeys

Dose group	Total animals affected (%)	Total affected lung sections	Total examined lung sectionsa	Lung sections affected (%)
Controlb	10 (50)	11	581	1.9
(n = 10/sex)
20 mg/kg	6 (60)	9	290	3.1
(n = 5/sex)
50 mg/kg	4 (40)	4	294	1.4
(n = 5/sex)
200 mg/kg	3 (33)	3	261	1.2
(n = 5/sex)

Thromboembolic events defined as the occurrence of a thrombus or an organizing thrombus (intimal hyperplasia was not observed in this study); ^atotal number of lung sections examined in each group = 29/animal; ^btreated with i.v. saline