Table 4.
Dose group | Total animals affected (%) | Total affected lung sections | Total examined lung sectionsa | Lung sections affected (%) |
---|---|---|---|---|
Controlb | 10 (50) | 11 | 581 | 1.9 |
(n = 10/sex) | ||||
20 mg/kg | 6 (60) | 9 | 290 | 3.1 |
(n = 5/sex) | ||||
50 mg/kg | 4 (40) | 4 | 294 | 1.4 |
(n = 5/sex) | ||||
200 mg/kg | 3 (33) | 3 | 261 | 1.2 |
(n = 5/sex) |
Thromboembolic events defined as the occurrence of a thrombus or an organizing thrombus (intimal hyperplasia was not observed in this study); atotal number of lung sections examined in each group = 29/animal; btreated with i.v. saline