Figure 6. FAK, PYK2, p-GSK3βY216 and β-catenin positively correlate in human colorectal cancer tissues.
(A) Hematoxylin and eosin (H&E) and immunohistochemical staining of the colorectal adenoma, carcinoma and adjacent normal tissues from a single patient. (B) 34 tumor samples on tissue microarray were immunohistochemical stained and scored. Score distribution and average score of each antibody staining were summarized. (C) Scoring differences between tumor and matched normal tissues from twenty-six patients. * Denotes p-GSK3βY216, FAK or PYK2 scores in different directions. _ highlights the numbers of patients whose TMA scores of p-GSK3βY216, FAK or PYK2, and β-catenin move in the same direction. (D) Hematoxylin and eosin (H&E) and immunohistochemical staining of colorectal carcinoma and adjacent normal tissues from a familial adenomatous polyposis patient. (E) Schematic diagram of the FKA/PYK2/p-GSK3βY216/β-catenin axis and its role in intestinal tumorigenesis.