Fig. 2.

Reduced expression between Q₅₆-YFP and Q₀-YFP yeast cells. a Network of genes down-regulated in Q₅₆-YFP cells compared to Q₀-YFP cells. Genes are colored in accordance to their log differences (100 % green: log₂ > 2, 75 % green: 2 > log₂ > 1.5, 50 % green: 1.5 > log₂ > 1, 25 % green: 1 > log₂ > 0.5, white: 0.5 > log₂ > −0.5, 25 % red: −0.5 > log₂ > −1, 50 % red: −1 > log₂ > −1.5, 75 % red: −1.5 > log₂ > −2, 100 % green: −2 > log₂). Hits with a p-value smaller than 0.05 were indicated by a greater font size (for details see Additional file 2). Pink frames highlight predicted co-regulated genes listed in Additional file 3. The smaller font size was additionally used for the predicted coregulators. For a detailed description of the data analysis see the methods section. Red boxes highlight clusters according to cellular pathways. b Analysis of predicted co-regulators within Fig. 2a. The line shows the number of genes within the respective category, while the vertical bar chart indicates the percentage of the genes predicted by the SPELL-correlations. If bars for all expression categories have the same height no significant enrichment in the predicted genes would be reported, which would indicate a non-significant clustering analysis