Table 1.
Suppressors of Q56-YFP toxicity
| Gene knockout | Strain number | Gene function | Growth of Q56-YFP |
|---|---|---|---|
| arg82Δ | 3531 | Inositol polyphosphate multikinase (IPMK) | -- |
| atp15Δ | 1021 | Epsilon subunit of mitochondrial ATP synthase | -- |
| cem1Δ | 198 | Mitochondrial beta-keto-acyl synthase | -- |
| his7Δ | 3388 | Imidazole glycerol phosphate synthase | --- |
| hom6Δ | 6933 | Homoserine dehydrogenase | -- |
| ies2Δ | 1997 | Essential for growth under anaerobic conditions | -- |
| kre28Δ | 4366 | Subunit of a kinetochore-microtubule binding complex | -- |
| map1Δ | 5153 | Methionine aminopeptidase | -- |
| ncl1Δ | 3050 | S-adenosyl-L-methionine-dependent tRNA | --- |
| nfu1Δ | 4889 | Protein involved in iron metabolism in mitochondria | -- |
| rpb9Δ | 4437 | RNA polymerase II subunit | -- |
| rrn10Δ | 3051 | Subunit of UAF (upstream activation factor) for RNA polymerase I | --- |
| ugo1Δ | 4304 | Outer membrane component of the mitochondrial fusion machinery | -- |
| ybr196c-aΔ | 7457 | Putative protein of unknown function | -- |
Genes, whose knock-out leads to an enhanced phenotype. The intensity of the phenotype is indicated on a semi-quantitative scale. --- : very strong toxicity, no residual growth, --: residual growth detectable, but stronger toxicity than in the WT background. Gene functions are annotated according to the yeast genome database