Fig. 2.—

Statistical overrepresentation of the human CNE enhancer target genes for the molecular function and biological process categories. There were in total 109 target gene bodies for a data set of 100 human CNE enhancers analyzed in the present study. Statistical analysis of these gene bodies for particular GO categories, by using all genes in the human genome as a reference, was performed by using a binomial statistics tool (Thomas et al. 2006). (A) The test highlighted significant overrepresentation of enhancer target genes for transcriptional regulation, DNA binding, nucleic acid binding, and transcription factor activity. (B) In the biological process category, embryonic development, nervous system development, nucleic acid metabolism, and transcriptional processes were significantly overrepresented (P < 0.01) along with other developmental processes.