Fig.2. The enhancer of the ACT gene is functional in astrocytes but not in hepatoma cells.
Human astrocytes or HepG2 cells were transfected with plasmids pΔACTCAT (ENH-ACTCAT) or pENHPCICAT and β-galactosidase expression vector as internal control for transfection efficiency. One day after transfection cells were stimulated with IL-1 (10 ng/ml) or TNF (10 ng/ml) in the presence of 1 μM dexamethasone, cultured for another 24 hours, and harvested. CAT activities were normalized to β-galactosidase activities (four separate analysis), and are shown as a fold induction with control cultures equal to 1.