Table 1.
Summary of GEMMs.
| REFERENCE | TRANSFORMING GENES | METHOD OF INDUCTION | TISSUE ORIGIN | HISTOLOGY |
|---|---|---|---|---|
| Flesken-Nikitin et al34 | Tp53, Rb1 | Injected Cre adenovirus-induced knockout | Ovary | Serous epithelial ovarian cancer |
| Szbova et al35 | Tp53, Rb “pocket proteins”, Brca1/2 | SV40 T antigen expression, Injected Cre adenovirus-induced knockout | Ovary | Serous epithelial ovarian cancer |
| Orulic et al36 | C-myc, K-ras, Akt1 | Syngeneic cells transduced with RCAS viral vectors injected into p53-null mice | Ovary | Undifferentiated carcinoma |
| Connolly et al40 | Tp53, Rb1 | Chimeric expression of SV40A under MISIIR promoter | Ovary | Poorly-differentiated neoplasia |
| Xing et al44 | C-myc, Tp53, Brca1 | Syngeneic cells transduced with RCAS viral vectors, Cre-induced knockout | Ovary | Serous epithelial ovarian cancer |
| Perets et al45 | Brca1, Brca2, Tp53, Pten | Cre-recombinase driven by Pax8 promoter | Fallopian tube | Serous tubal intraepithelial carcinomas |
| Sherman-Baust et al46 | Tp53, Top2A | Expression of SV40A under Ovp-1 promoter | Fallopian tube | Serous tubal intraepithelial carcinomas |
| Tirodkar et al47 | Pten, K-ras, Muc1 | Injected Cre adenovirus-induced knockout | Ovary, oviduct, and uterus | Endometrioid adenocarcinoma |
| Wu et al50 | Pten, Apc | Injected Cre adenovirus-induced knockout | Uterus | Endometrioid adenocarcinoma |